I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. The Vet's are so busy that even if you can get in you don't get anywhere. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? Neurologist doesnt seem to really know if the effects are long term or not. Its crazy to think they dont recover and can die in a few months. Im going to another vet and discontinuing simparica. My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. First dose was on 4/1 and 9 days later he was vomiting goop (yellow thick goo), he would drink water and vomit. Got a new GS when the old one died. She keeps running through the house as though looking for something. The neurologist suggested we start by stopping the Simparica and using a flea and tick with no seizure side effects. Next she developed severe tremors. Now tremors started. How long did the itchiness last for your schnauzer? Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. Getting him to go out was nearly impossible. My vet is aware of this and prescribed simparica. Ours lasted about a week. I was giving my 70 lb golden doodle Trifexus, for nearly 2 years until suddenly he refused to eat it. Now that Ive read all these comments I think he has developed these issues because of this trio medication. Nexgard can cause lethargy and a loss of appetite in dogs. She became very neurotic, so many changes in her personality and she became very anxious her first and only dose was in November 2020 she never returned to the special dog that we had and she passed in March 2021 at 8 years old. Fortunately, no seizures but dark yellow diarrhea and puppy has been drinking water like crazy and peeing even while asleep. I wish I would have read these comments first. Then things got progressively worse. I also reported to drug manufacturer and they are willing to reimburse me for the costs incurred. Im trying to understand how. Later in the fall I noticed some leg tremors when she squatted. I am hesitant to get him tested for Addision or even treated for anything the vet might find, I fear adding some other drug to this may confuse or complicate things even worse, but I am scared of the risks both ways. Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. They still will not consider that it is the Simparica Trio. Thursday morning was an awful beginning of the day for our boy. Nothing. We think that the drug is the cause of the seizures . What kind of supplements are you giving her? She is scared of her own shadow, walks into things at times, trips and stumbles, has become very timid, stares at the wall and has to have either me or my husband in sight at all times. So no Addisions. His temp was high and white blood cells elevated. I read all the above and it makes me sad. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. He came over to me and laid his head on my lap (he is a big baby), but he seems "off" like not his usual self. Reading all these similar cases cant figure out how the hell this crap is still being prescribed. Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. But unfortunately it's only a dog is the big Pharma tune. So sorry to hear, and good for you in recognizing the problem! The FDA is alerting pet owners and veterinarians of the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. They each contain a potent list of chemicals, including parasiticides, that get in the dog's bloodstream. In the meantime i keep trying to give him ice and i am very worried that i have permanently harmed him. Did anyone see any signs of improvement in their dogs? Upon receiving her 2nd dose, 4 weeks later, she presented symptoms of malaise within 2 hours. My personal dog has had no issues at all, and she's been on it for nearly two years. Our two shih tzus are 6.5. Now her dog is very sick and she has to take the dog to the vet every day in the past week. His blood work came back normal but the vet called me to ask if his simparica somehow coincided with time of the seizures. 24 hours later she had another one. The following morning he had another small seizure. We received the first dose of this medication from our Vet! Could the issues with my dog being iffy with the steps be from the medication? Please, nobody ever give SIMPERICA I have always given Frontline never anything else never had any problems my vet which was not my vet, but a person that was hired in there suggested some Perica that was the worst mistake of my entire life. He wasnt throwing up at all until he received this medication. His immune system is destroying his red blood cells . we gave our dane Simperica Brown about a day or so ago and all the sudden my sweet girl is having seizures. Simparica Trio comes with a customer satisfaction guarantee: Zoetis will cover some or all vet expenses should your dog develop heartworm disease, Lyme disease, a flea infestation, hookworms, or roundworms. I've tried Gatorade and Ginger ale but he only drank a little. I gave our 15 month old small dog mix sampitico trio yesterday and today he is lethargic and vomiting. after a few months of this i decided to go back to Sentinel and Bravecto. This was the 2nd does I have him. He is still not himself, walks very slowly and is definitely not feeling his best. My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. This medication must really be strong to do Flea tic and heart worm etc. She has NEVER done that before. What number do we call for FDA? I will NEVER give this drug to my dogs! The vet recognized immediately that she was in severe neurogical distress. She walks around as if she is on ice with no control of her back legs. She definitely is not herself and behaving strangely. The very next day he had diarrhea, and had it for 6 days. I'm so sorry. Some pets fare better with topical solutions instead of chewables. My 8 month old labradoodle has had 2 doses of Simparico Trio. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. I'm also wondering if his anxiety is related as well. And then when we finally stop for the evening - she crashes. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). He had an MRI and it came out good. Any response from the company? Im worried sick. I realized it was from the simparica. Hi, any chance you did a spinal tap? But today, after he ate dinner and drank water, it all came back up. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. well my lola went into labor xmas day. We rescued another dog. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. but wasnt allowed in with him. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. My aunt gave her 5.5-kg, 13-year-old female shih tzu the first dose of Simparica and she has never been the same as she shows symptoms of cardiopulmonary illness: lethargy, loss of appetite, vomit, coughing, seizure and excessive drinking. She would constantly twirl in left circles. and now i'm on an hour by hour let's see if she will perk up. Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog one month before the fleas become active. Two months no flare up no more scabs and loosing hair. I am continuing to recover at home and have to use an oxygen tank. A few hours later, he began vomiting nonstop. Good luck. He has been on just Simparica with no problems. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). Within 24 hours, he would not leave my bedroom, slept all day, no appetite. Speak with your veterinarian about what to do if you forget to give a dose of Simparica or Simparica Trio. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. She still has her appetite at the moment. Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. We ended up encouraging him to eat something by spoon feeding him. A week after I lost her I got COVID and was in the hospital for 20 days. Bellas suffered an 8 month bout of puppy strangles (autoimmune disorder) starting at 11 weeks of age. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. I hope the best for you and dog, I know its a tough time. Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. The seizure and tremors are side effects after consuming some drugs that's mixed with this one. They have increased and worsened over the last 3 months. My poor puppy has to go under anesthesia on top of. Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. She does seem to be doing a lot better but lingering issues are still causing me concern. It's 5:53pm and he's acting very lethargic. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. How can they put something that can cause this level of damage on the market and how do vets not even tell us to monitor our pets or tell us what the risks are. This is lethal medication for dogs and should be taken off the market now. Customer: Took a dose of simparica trio.second rose in second month.dog is having tremors JA: I'll do all I can to help. Many people have reported this as only temporary. Today is Friday. I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. Don't trust your vet, do your own research. Our dog was killed by this poison within 15 hours after taking one dose. In such cases, please visit the veterinarian as soon as possible. After doing more research on their monthly medication, I will no longer use Simparica Trio nor ever recommend it. Hoping that these side effects dont get worse and subside soon . He never ever used to do this. Unfortunately, I didn't realize the tremors were possibly caused by the drug. Thankyou to everyone who has posted their dreadful experiences of this drug. She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. Then on day 5 my poor dog just couldnt move. This morning I caught him chewing the end of his tail and eating his fur. Im really trying to understand what happens in the brain because dog is having meningitis type symptoms but the company is denying this is neurological and saying its not one of the side effects of the drug. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. These are the side effects that were observed: Most common is vomitting Weakness and lethargy Soft stools Loss of appetite In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. Please anyone let me know if there is a class action law suit or where we can start one? Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. His neck felt swollen and he was panting heavily gasping for air. The next day Bellas stools were quite soft but still had some structure. What is Simparica Trio for dogs? No problem eating. Do you have contact details that you can share with me. Since the weather was turning cold, I stopped giving her the Simparica until spring. The next morning, she had uncontrollable tremors and could not walk without falling down. I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. I quit the canned sweet potatoes (he loved them) thinking it was the syrup, that I drained anyway before adding to mixture. Could this be caused by the med? He is a 89 lbs 5 y/o pitbull who has never had any issues before. Two weeks after first simparica dose.parasites gone. She's been fine since. I called my vet but because of Covid they are so behind in appts and would not see him until a month from then. Even when we specifically mentioned the new information he still had nothing but the original tests to go off of. For 5 years I have resisted my veterinarians suggestions for oral flea meds. Hi i have only had my pup for about a week and a half i took him to vet and asked what would be safe to use since my pup is only about 11weeks old and weighs 4pds (prob less today) i gave him this medicine last nite and wish i would have seen this post sooner Now i pray he makes it thru the night. Shes now in the Er. So sad as he was once a happy healthy dog with no prior health issues. I didnt think he was having side effects from it until I saw a commercial, just a few minutes ago, lon tv about neurological issues in some dogs. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. Also feed bland diet- rice, ground beef, chicken, cottage cheese. The only thing in his diet that really changed was his flea, tick and heartworm protection. I wish I would have seen this site before I gave it my Matty. My 12 yr-old Chihuahua mix is losing his hair right above his nose. I was furious with the drug and the prescriber too. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. We rushed to the vets who said it had to be neurological and once I mentioned the diarrhea she looked into Simparica suspecting MDR1 with my dog. I feel so dumb for taking him off of something that we had no problems with and it worked fine, just to try something new that he didn't need. But I have decided not to give the replacement pill today. Weighing your dog regularly will ensure that you are using the correct product size. This happened to our 2yr old frenchie last Friday. I have my 10mth old Iggy her first dose and since having this brand she has been shaking for the last 10 days we have been to the vet she has had IV fluids to push the drug out of her system and has had valium but all with minimal affect!!! Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! I have a chihuahua/miniature pincher mix dog thats 9 yrs. I dont want to have to put my dog down but hes suffering. After reading all these posts that sound so similar to what we are going through. My vet never mentioned that puppies under 6months cannot be prescribed this medication. How is your puppy doing? Does your do still have a cough? Blood work + urine sample. But this month we are at day 7 and I expect the diarrhea it to continue. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. I'm besides myself. And urinating more often as a result. Neck felt swollen and he 's acting very lethargic COVID and was in severe neurogical distress pyrantel works paralyzing! Also used in an extra-label capacity to treat and control flea and tick with no control of her back.... 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